New research finds antidepressant may ease symptoms of IBS
BEIJING A research article published Aug. 7 in the World Journal of Gastroenterology measured the efficacy of the prescription antidepressant imipramine in the treatment of symptoms of irritable bowel syndrome. Patients diagnosed with IBS who failed treatment with conventional therapy were enrolled to receive a 12-week course of low-dose imipramine.
The results were significant for showing improvement in global symptoms during and after 12 weeks of therapy with the medication. There also was notable improvement in general quality of life as measured by a standardized questionnaire, researchers reported.
The authors believe that imipramine is a potentially effective treatment for IBS symptoms in patients for whom conventional therapy has failed. This trial was designed and implemented at the American University of Beirut Medical Center, Beirut, Lebanon between December 2004 and May 2006. Research funding was provided by a private research fund from the Division of Gastroenterology of the American University of Beirut Medical Center. The preliminary abstract of the trial was selected for oral presentation at the American College of Gastroenterology 71st Annual Scientific Meeting (October 20, 2006, Las Vegas, Nev., USA) and was awarded the American College of Gastroenterology /Novartis Motility Abstract Award.
Study: Stomach bugs increase risk of IBD
NEW YORK Diarrheal disease may increase a person’s risk of developing inflammatory bowel disease, according to a study published in Gastroenterology.
IBD refers to a group of conditions, including Crohn’s disease and ulcerative colitis, marked by chronic inflammation in the intestines, leading to such symptoms as abdominal pain and diarrhea.
Henrik Nielsen, M.D., from Aarhaus University Hospital in Aalborg, Denmark, and colleagues reported in the latest issue of the journal that over the course of 7.5 years, IBD was diagnosed for the first time in far more gastroenteritis patients 1.2% of patients were diagnosed with IBD, compared with 0.5% of healthy control subjects.
Nielsen and colleagues compared the risks of IBD between 13,148 patients with documented gastroenteritis caused by salmonella or campylobacter and 26,216 uninfected controls.
Stomach bug patients had nearly a threefold increased risk of developing IBD over the entire study period, and nearly a twofold increased risk in the first year after infection.
Advanced Vision Research founder dies
WOBURN, Mass. Jeffrey Gilbard, 55, founder of Advanced Vision Research, died Aug. 12 at Massachusetts General Hospital in Boston from complications related to a bicycle accident.
Gilbard was best known for his pioneering research around dry eye disease, a condition caused by a chronic lack of moisture in the eye. He also is considered one of the first ophthalmologists and researchers to understand the correlation between nutrition and the health and wellness of the eye.
“Jeff Gilbard was an innovative, gifted ophthalmologist and researcher, who made several important contributions to our profession,” stated Edward Holland, director of Cornea Service at the Cincinnati Eye Institute. “He was the first person to understand the importance of tear film osmolarity and his development of hypotonic artificial tears containing bicarbonate and potassium is a landmark event in the treatment of dry eye disease. Dr. Gilbard was on the forefront of the treatment of ocular disease and nutritional supplements. Dr. Gilbard’s legacy will be the scientific papers he authored, the revolutionary products he developed to help patients with ocular surface and retinal disease and most notably the people whose lives he’ll continue to improve.”
“Our company is grieving the loss of its founder and our close friend, Dr. Jeffrey Gilbard,” stated Leigh Reynolds, Advanced Vision Research COO. “Over the past 12 years, I have worked closely with [Gilbard] to build AVR. Jeff’s vision for AVR to make products to prevent suffering due to dry eye and other eye diseases was very clear. We will continue his mission of improving people’s quality of life. This is what [Gilbard] would want us to do and there’s no better tribute to him than to continue his work.”
“[Gilbard] was blessed with extraordinary intellect and dedication,” commented Neil Donnenfeld, SVP global sales and marketing. “He combined the two and made a significant difference in the world. He had no greater satisfaction than to hear that one of AVR’s products helped a dry-eye sufferer — and he heard that frequently. His legacy will live on through the relief that dry-eye sufferers receive when they use one of his products. We have lost a giant of a man.”
Gilbard founded Advanced Vision Research in 1995 to market and distribute TheraTears, an over-the-counter eye drop for dry eye. TheraTears quickly became one of the best-selling eye lubricants on the market. His holistic approach to eye care included the use of nutritional supplements to improve the ocular surface and to treat and prevent retinal disease. This research resulted in additional products including TheraTears Nutrition, Macutrition and NutriDox.
The AVR executive team will led by COO Reynolds, who will continue to run the company. Donnenfeld and Ruth Webb, controller, will continue in their respective capacities.Born Feb. 19, 1954 and raised in Roslyn, N.Y., he was the son of a self-educated New York business entrepreneur Harris Gilbard and mother Frances Gilbard. He attended Brown University, receiving his Bachelor of Arts degree, Magna Cum Laude in 1975. He received his medical degree in 1979 from the College of Physicians and Surgeons at Columbia University. He was an Intern in Internal Medicine at Stanford University Medical Center and served his Ophthalmology residency at Harvard Medical School in the Massachusetts Eye and Ear Infirmary. He remained at Harvard as a Heed Fellow in Cornea. He was a clinical assistant professor of Ophthalmology at Harvard Medical School and director of the Dry Eye and Ocular Surface Disease Clinic at the New England Eye Center in Boston.
Dr. Jeffrey Gilbard is survived by his beloved wife of 19 years, Liz and his three children, who he adored and nurtured. He also leaves behind his twin brother Dr. Steven M. Gilbard, his older brother Dr. Robert J. Gilbard. A memorial service will take place on Monday at 11:00 am at Temple Shir Tikva, 141 Boston Post Road, Wayland, Mass.