Horizon: Lodotra reduces RA symptoms in patients in trial
NORTHBROOK, Ill. An investigational drug for rheumatoid arthritis significantly reduced symptoms in patients, according to results of a late-stage clinical trial announced Wednesday.
Horizon Pharma presented data from two three-month phase 3 studies of Lodotra, a modified-release formulation of the drug prednisone, at the 11th annual congress of the European League Against Rheumatism in Rome. The studies included a 350-patient U.S. trial comparing Lodotra with placebo, while the 288-patient European study compared Lodotra with an immediate-release formulation of prednisone.
In the U.S. study, 48.5% of those receiving the drug had a 20% reduction in symptoms, the study’s primary goal, compared with 28.6% of those taking placebo. In addition, 22.7% of those in the Lodotra group had a 50% reduction in symptoms, compared with 9.2% of those in the placebo group.
In Europe, 22.7% of those taking Lodotra showed a reduction in the duration of morning stiffness, compared with 0.4% of those taking immediate-release prednisone. A 12-month open-label study followed the European trial, with 55% of those taking Lodotra having a reduction in morning stiffness, compared with 45% of those who had switched from immediate-release prednisone to Lodotra.
“Conditions like rheumatoid arthritis follow a very distinct circadian rhythm, in which symptoms are more severe at a specific time of day,” said Frank Buttgereit, a doctor in the Department of Rheumatology and Clinical Immunology at Berlin’s Charite Hospital. “In the case of RA, many patients feel stiff when they wake up, and it has the potential to negatively impact their quality of life.”
JumpStart Dual makes retail debut
AVENEL, N.J. Digipower, a division of Mizco International, has introduced a portable AC adapter with a built–in rechargeable battery back-up.
The JumpStart Dual, available at retailers nationwide for $49.99, provides mobile device enthusiasts with two powerful products in one solution. Designed to support mobile phones, MP3 and other portable devices, JumpStart Dual comes with two USB ports for simultaneously charging two devices, built-in short circuit, over-charge, and temperature protection; a two-step LED display that shows both charge status and battery life; power on/light function, an emergency flashlight, and a 5V USB output.
“JumpStart Dual combines power and innovation in one portable solution and that’s the philosophy that drives our entire product development program,” said Digipower president Maurice Mizrahi. “There is no other portable power device currently on the market that combines an AC adapter with a built-in rechargeable battery back-up. JumpStart Dual is designed to meet all of the power requirements of today’s power hungry consumers.”
Kodak looks to capture wedding bliss
ROCHESTER, N.Y. Kodak is looking to make weddings even more memorable with the launch of its new line of single-use cameras.
Two new Kodak wedding single use cameras — available in red and blue — and bachelorette edition in teal, were launched with the help of wedding website TheKnot.com. Additionally, an exclusive edition of the camera — Forever Floral — only can be found on the site.
The new camera will be available at a special introductory price of $5.99.
“2010 is a year of the fun, modern bride, so Kodak has introduced these four new camera designs to reflect the personality of today’s brides and complement almost any color scheme,” said Therese Corrigan-Bastuk, worldwide marketing director, film capture, paper and output systems, Eastman Kodak Co. “The stylish new designs for the new line of single use wedding cameras make for great looking cameras that provide great looking pictures by using high quality 800-speed Kodak film, making it easy to capture and share all of your Kodak moments.”