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Takeda: Edarbyclor statistically superior in reducing blood-pressure levels among hypertension patients

BY Allison Cerra

DEERFIELD, Ill. — A Takeda drug designed to treat hypertension was statistically superior to another drug combination in reducing systolic blood pressure among patients in a 10-week, late-stage clinical trial.

Published in the American Journal of Medicine, Takeda said a fixed-dose combination of its drug Edarbyclor (azilsartan medoxomil and chlorthalidone) was significantly greater at six and 10 weeks than those of azilsartan medoxomil co-administered with hydrochlorothiazide. For instance, primary endpoint data showed that at week six, the clinic SBP reductions of the fixed-dose combination of azilsartan medoxomil and chlorthalidone was 35.1 mm Hg, compared with 29.5 mm Hg among those taking azilsartan medoxomil and hydrochlorothiazide. At the end of 10 weeks, greater clinic SBP reductions were maintained in patients taking the fixed-dose combination of azilsartan medoxomil and chlorthalidone (37.8 mm Hg) versus those taking azilsartan medoxomil and hydrochlorothiazide (32.8 mm Hg). Data also showed that more patients achieved their target blood-pressure levels at the end of six and 10 weeks (secondary endpoints) when taking the azilsartan medoxomil and chlorthalidone fixed-dose combination.

"Hypertension management can be complex and the use of combination therapy with a diuretic is a common treatment approach,"said study co-author William Cushman, professor of preventive medicine at the University of Tennessee College of Medicine in Memphis, Tenn. "While hydrochlorothiazide is more commonly used in clinical practice, this study provides further support for the use of chlorthalidone in fixed-dose combination for patients with hypertension."


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MOM Brands augments Three Sisters cereal line

BY Allison Cerra

MINNEAPOLIS — MOM Brands has boosted its Three Sisters cereal line with the addition of two new varieties.

Free of artificial flavors or preservatives, saturated fat, trans fat or cholesterol, the new multigrain berry and multigrain cinnamon varieties are made with whole grain oats, whole grain barley and whole grain triticale (a cross between wheat and rye with higher levels of essential amino acids), boasting 43 g of whole grains per serving. What’s more, both flavors also carry the 100% whole grains stamp from the Whole Grains Council, the company said.

The new cereals now are available at stores nationwide.

"We’re always looking for better ways to provide consumers with better breakfast options, which means giving consumers a wide selection of tasty and affordable cereal," said Linda Fisher, director of corporate communications. "Three Sisters is also a smart cereal choice that’s more sustainable for the environment as our cereal is packaged in bags instead of boxes. That’s 75% less consumer packaging compared to comparably sized boxed cereals with an interior liner bag."

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Reports: Obama gets support from former Costco CEO

BY Alaric DeArment

NEW YORK — President Barack Obama’s re-election bid got a dose of support from the cofounder of one of the country’s largest retailers, according to published reports.

Speaking at the Democratic National Convention, former Costco Wholesale CEO and cofounder Jim Sinegal said Obama "understands what the private sector needs to succeed," The Seattle Times quoted the co-founder of Issaquah, Wash.-based Costco as saying.

Sinegal, who cofounded the club retailer in 1983, retired as CEO of Costco on Jan. 1, 2012, replaced by Craig Jelinek. In January, investment research firm Morningstar named Sinegal as its "2011 CEO of the Year," citing his "exemplary corporate stewardship, independent thinking" and his having created "lasting value for shareholders."

The newspaper reported that Sinegal, a longtime donor and supporter of the Democrats, was part of an effort by the party to present itself as pro-business and challenge the reputation of the Republicans as being the party more favorable to business interests.

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