PHARMACY

Study: Levemir may lower average blood sugar in patients with Type 2 diabetes

BY Alaric DeArment

PRINCETON, N.J. An injected insulin made by Novo Nordisk substantially lowered average blood sugar in patients with Type 2 diabetes, according to results of a study released recently.

The Danish drug maker said Levemir (insulin detemir [rDNA origin]) taken once daily substantially lowered average blood sugar, and patients taking it took a more active role in their treatment by adjusting their own dosing after receiving trained from physicians. About 60% of patients taking Levemir once a day reached the American Diabetes Association’s recommended average blood sugar level, Novo Nordisk said.

“Teaching and empowering patients to adjust their own insulin doses can help them achieve good blood sugar control,” said Lawrence Blonde, director of the diabetes research unit at the Ochsner Medical Center in New Orleans. “These findings showed that following a self-adjustment dosing schedule of Levemir once daily resulted in a majority of patients reaching the target blood sugar level that the ADA recommends for most patients.”

The study, called the TITRATE study, appeared online this week in the journal Diabetes, Obesity & Metabolism.

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Warner Chilcott to relocate to Ireland

BY Alaric DeArment

ARDEE, Ireland The board of directors of Warner Chilcott has voted unanimously to move the company’s headquarters from Hamilton, Bermuda, to Ireland, the company announced Monday.

Warner Chilcott has kept its headquarters in Bermuda since 2005, but plans to finish the relocation during the second half of this year, changing its name from Warner Chilcott Limited to Warner Chilcott plc. The company said its relocation would offer shareholders a stable long-term legal and regulatory environment.

Warner Chilcott has had a presence in Ireland since 1996.

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Heartburn drugs’ interaction with anti-clotting drug may raise risk of heart attack

BY Alaric DeArment

FRANKLIN LAKES, N.J. Four popular drugs used to treat heartburn may raise the risk of heart attack in patients taking a cardiovascular drug, according to a recent study presented at the annual scientific meeting of the Society for Cardiovascular Angiography and Interventions.

Researchers at pharmacy benefit manager Medco Health Solutions and the Indiana University School of Medicine found that four proton-pump inhibitors – Wyeth’s Protonix (pantoprazole), AstraZeneca’s Nexium (esomeprazole) and Prilosec (omeprazole), and Takeda Pharmaceuticals’ Prevacid (lansoprazole) – could reduce the effectiveness of Sanofi-Aventis’s and Bristol-Myers Squibb’s anti-platelet drug Plavix (clopidogrel), thus raising the risk of heart attack and stroke. Other proton-pump inhibitors were not included in the study due to the low number of patients taking them.

“There’s a growing body of evidence that PPIs decrease the effectiveness of clopidogrel and put cardiovascular patients at a much higher risk, a huge concern given the large number of patients affected,” Medco chief medical officer and study researcher Robert Epstein stated. “While this study confirms prior research in this area, it brings us a step further in our understanding by showing that this is a problem associated with each of the four most popular PPIs.”

The study, part of the Clopidogrel Outcomes Study, investigated pharmacy claims data of 16,690 patients taking Plavix following a stent procedure and tracked the subjects for a 12-month period from 2005 to 2006, comparing 6,828 patients taking Plavix and a proton-pump inhibitor to 9,862 taking Plavix alone.

“Our study, along with a 2007 FDA review and other researchers’ work, provides strong evidence that PPIs do not independently raise cardiovascular risks for stent patients, and further strengthens the observation that this interaction exists between PPIs and clopidogrel and impairs the effectiveness of the anti-platelet drug,” Epstein said.

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