HEALTH

Report: Reckitt Benckiser to make acquisition

BY Michael Johnsen

SLOUGH, England The U.K. Telegraph on Thursday morning reported that a major Reckitt Benckiser acquisition was imminent.

Speculating on possible targets, the Telegraph identified Colgate-Palmolive, which fields the Colgate branded dental health products. But also in the rumor mix was the U.K. consumer healthcare group SSL International, parent company of Durex.

keyboard_arrow_downCOMMENTS

Leave a Reply

No comments found

TRENDING STORIES

POLLS

Which area of the industry do you think Amazon’s entry would shake up the most?
HEALTH

Scientists closer to finding cause of IBD with new analyses

BY Michael Johnsen

PHILADELPHIA In the largest, most comprehensive genetic analysis of childhood-onset inflammatory bowel disease, an international research team has identified five new gene regions, including one involved in a biological pathway that helps drive the painful inflammation of the digestive tract that characterizes the disease.

A research team led by Hakon Hakonarson, director of the Center for Applied Genomics at The Children’s Hospital of Philadelphia, reported on Sunday that the findings advance the scientific understanding of how IBD develops.

“This is an evolving story of discovering what genes tell us about the disease,” stated Robert Baldassano, a co-first author of the study and director of the Center for Pediatric Inflammatory Bowel Disease at Children’s Hospital. “Pinpointing how specific genes act on biological pathways provides a basis for ultimately personalizing medicine to an individual’s genetic profile.”

The study appeared online Nov. 15 in Nature Genetics.

IBD is a painful, chronic inflammation of the gastrointestinal tract, affecting about 2 million children and adults in the United States. Of that number, about half suffer from Crohn’s disease, which can affect any part of the GI tract, and half have ulcerative colitis, which is limited to the large intestine.

Most gene analyses of IBD have focused on adult-onset disease, but the Center for Applied Genomics — one of the world’s largest pediatric genotyping programs — at Children’s Hospital has concentrated on childhood-onset IBD, which tends to be more severe than adult-onset disease. The researchers performed a genome-wide association study on DNA from more than 3,400 children and adolescents with IBD, plus nearly 12,000 genetically matched control subjects, all recruited through international collaborations in North America and Europe.

Some current IBD drugs are monoclonal antibodies that act on another cytokine, called tumor necrosis factor, which contributes to inflammation. Although much research remains to be done, the current study may provide a basis for developing drugs that target the cytokine IL-27’s action, for patients with the disease-causing gene variant.

keyboard_arrow_downCOMMENTS

Leave a Reply

No comments found

TRENDING STORIES

POLLS

Which area of the industry do you think Amazon’s entry would shake up the most?
HEALTH

FDA: Anti-clotting drugs, PPIs may adversely affect each other

BY Alaric DeArment

ROCKVILLE, Md. Patients taking an anti-clotting drug should avoid the use of a drug for gastroesophageal reflux disease, the Food and Drug Administration warned Wednesday.

The FDA is advising patients using Bristol-Myers Squibb’s and Sanofi-Aventis’ Plavix (clopidogrel) to avoid taking prescription and OTC versions of AstraZeneca’s Prilosec (omeprazole) following data showing that Prilosec’s blocking of a certain liver enzyme may reduce Plavix’s anti-clotting effect by about 50%.

“Both of these drugs, when used properly, provide significant benefits to patients,” FDA Center for Drug Evaluation and Research Division of Cardiovascular and Renal Products scientist Mary Southworth said in a statement. “However, patients at risk for heart attacks or strokes who use Plavix to prevent platelet aggregation will not get the full effect of this medicine if they are also taking Prilosec.”

Plavix is used to prevent blood clots that could lead to heart attacks or strokes. Prilosec, which belongs to the drug class known as proton-pump inhibitors and is available in branded and generic versions, is used to prevent such symptoms of GERD as heartburn. But Prilosec also blocks the liver enzyme CYP2C19, which Plavix needs to be metabolized. It is unknown how other proton-pump inhibitors may interact with Plavix.

The FDA based its decision on studies prompted by reports in January that use of Prilosec could diminish the effectiveness of Plavix.

keyboard_arrow_downCOMMENTS

Leave a Reply

No comments found

TRENDING STORIES

POLLS

Which area of the industry do you think Amazon’s entry would shake up the most?