Pair of drugs may help even sedentary lose weight
LA JOLLA, Calif. Researchers at the Salk Institute in San Diego reported that they had found two drugs that did wonders for the athletic endurance of “couch potato” mice, according to published reports. One drug, known as AICAR, increased the mice’s endurance on a treadmill by 44 percent after just four weeks of treatment.
A second drug, GW1516, by GlaxoSmithKline, supercharged the mice to a 75 percent increase in endurance but had to be combined with exercise to have any effect.
After starting the mice off with just GW1516, the researchers then gave the mice a combination of GW1516 and AICAR, which triggers the body to make a protein that is normally produced during exercise to signal that it should burn more energy. In sedentary mice, AICAR activates the energy sensor and imitates exercise. In fact, 20 doses of AICAR treatment is like 20 days of exercise for the mice, turning them into runners.
The results, according to Ronald Evans, leader of the Salk group, seem reasonably likely to apply to people, who control muscle tone with the same underlying genes as do mice. If the work can be transferred to humans, Evans said it may have potential for treating people with certain muscle diseases, as well as helping hospital patients, veterans and people with obesity maintain a minimum fitness level.
Gestational diabetes results in increased risk for Type 2 diabetes
NEW YORK Gestational diabetes greatly increases a woman’s risk of developing Type 2 diabetes later on in life, a new study confirms, according to Reuters.
Gestational diabetes is a known risk factor for Type 2 diabetes. Denice Feig of the University of Toronto and her team looked at 633,449 women who gave birth in Toronto between 1995 and 2002. A total of 21,823 (3.3 percent) of the women were diagnosed with gestational diabetes.
While just 2 percent of the women who didn’t have gestational diabetes went on to develop Type 2 diabetes during the 9-year follow-up period, 19 percent of those with gestational diabetes did, the researchers found.
Moreover, they say the strongest risk factor for Type 2 diabetes was gestational diabetes, which increased risk more than 37-fold.
Russian antihistamine appears effective against Alzheimer’s
NEW YORK A study that lasted a year and a half has found that an antihistamine developed in the former Soviet Union may be able to stabilize Alzheimer’s disease.
The study, presented at the International Conference on Alzheimer’s Disease, found that the drug Dimebon could stabilize the disease for at least the time of the study. Researchers tested the drug against a placebo in 183 patients in Russia who had mild to moderate Alzheimer’s.
Conditions of patients who received the placebo deteriorated, while those of the people who received Dimebon improved or deteriorated only slightly.