Optivia, FDA collaborate to identify potentially harmful drug-dietary supplement interactions
MENLO PARK, Calif. — Optivia Biotechnology on Tuesday announced that the company and the Food and Drug Administration have signed a collaboration agreement to assess the effect of dietary supplements on key drug transporters.
Drug transporters are proteins on the surface of cells that either facilitate or hinder the transport of nutrients or pharmaceuticals. Drug transporters can increase or decrease the absorption of drugs into the body, as well as limit or facilitate the exposure of certain organs.
The goal of the Optivia-FDA collaboration is to identify potentially harmful drug-dietary supplement interactions, such as an interaction with acetaminophen and other drugs associated with liver toxicity, the company stated.
Drug-induced liver toxicity is estimated to be responsible for as many as 5% of all hospital admissions and 50% of all acute liver failures. It is well-established that transporters greatly influence the disposition by the liver of a number of commonly used drugs (e.g., antibiotics, statins and hypoglycemic agents) and others that subsequently were removed from the market (e.g., the antidepressant nefazodone).
The research collaboration will assess the ability of dietary supplements, including black cohosh, green tea, gingko biloba, kava, usnic acid and potentially others, to affect various drug transporters. As a starting point, the seven transporters cited by the International Transporter Consortium and the FDA as the most clinically relevant to transporter-related drug-drug interactions will be examined.
Fish oil, multivitamins among top dietary supplements used by consumers
WHITE PLAINS, N.Y. — Among people who use dietary supplements, the most popular products in 2010 were fish oil, multivitamins, vitamin D, calcium and Co Q10, according to a survey released Tuesday by ConsumerLab.com.
Women were much more likely than men to have taken vitamin D, calcium or probiotics. Men were more likely than women to have taken Co Q10, herbs and extracts, glucosamine/chondroitin, vitamin E, resveratrol, amino acids, and nutrition drinks and powders.
Use of vitamin D surged in 2010 to 56.2% of those surveyed, up from 47.9% in 2009 and 36.9% in 2008. Fish oil continued its rise in popularity, used by 75.7% of those surveyed, up from 74% in 2009.
Multivitamin use declined to 70.1% last year from 72.0% in 2009 and 73.8% in 2008. Younger adults, however, were more likely to have used a multivitamin than older adults; 73% of people ages 35 to 44 years used a multivitamin, compared with 67.9% of those ages 75 to 84 years. Younger adults also were more likely than older adults to have used amino acids, nutrition/protein drinks and powders, green tea, nutrition bars and iron.
Survey: Tech helps relieve care burden on sandwich boomers
BETHESDA, Md. — It’s technology, and lots of it, that will be relieving the burden of caregiving for today’s sandwich generation — those baby boomers faced with caring for their senior parents while at the same time managing a teenager at home.
A new survey released last month by the National Alliance for Caregiving and UnitedHealthcare found that more than two-thirds of family caregivers are interested in technology to help them with caregiving.
Slightly more than 3-in-4 caregivers reported that a website or computer software that could help them keep track of their care recipient’s personal health records — including his or her history, symptoms, medications and test results — would be very or somewhat helpful to them; 70% of caregivers indicated that a shared electronic log for their loved one’s doctor appointments and other caregiving needs would be helpful; and electronic medication reminders and/or dispensers were on the mind of 70% of caregivers surveyed.