HEALTH

Nutrisystem gearing for national retail launch

BY Michael Johnsen

FORT WASHINGTON, Pa. — Nutrisystem will make a national retail launch in 2014, noted Dawn Zier, Nutrisystem president and CEO, during a conference call Wednesday. The company already has distribution through 2,500 Walmart locations and will be introducing its weight loss kits into Target in the second quarter. 

"We successfully launched and tapped into 2,500 Wal-Mart stores for diet season 2014 and both the diet and diabetic kit as well as the shakes and snack pack continues to perform well," Zier said. "Channel expansion will be focused on mass and club with a test line approach before expanding nationally. Our first test is with Target in Q2," she said. "We are adding additional resources to our retail team to support our growth strategy."

Retail contributed $5.9 million in the quarter, representing 8.4% of total revenues. The company expects a $25 million from the retail channel in the next fiscal year. 

 

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New study suggests blood pressure should be measured in both arms

BY Michael Johnsen

PHILADELPHIA — New research published in the March issue of the American Journal of Medicine suggests that there is an association between a difference in interarm systolic blood pressure and a significant increased risk for future cardiovascular events, leading researchers to recommend expanded clinical use of interarm blood-pressure measurement.

While blood pressure is a widely used medical metric, most measurements are taken only using one arm. Measuring interarm blood pressure involves taking two readings, one for each arm. Increased interarm systolic blood pressure differences are defined as 10 mmHg or more, and while a link between interarm blood pressure and cardiovascular risk was suspected, little data existed to support the hypothesis until now. 

This new study examined 3,390 participants ages 40 years and older from the Framingham Heart Study. All subjects were free of cardiovascular disease at baseline, but investigators found that participants with higher interarm systolic blood-pressure differences were at a much higher risk for future cardiovascular events than those with less than a 10 mmHg difference between arms.

"In this large prospective, in a community-based cohort of middle-age men and women free of cardiovascular disease, an increased interarm systolic blood pressure difference was found to be present in nearly 10% of individuals and is associated with increased levels of traditional cardiovascular risk factors," explained lead investigator Ido Weinberg of the Institute for Heart Vascular and Stroke Care at Massachusetts General Hospital in Boston. "Furthermore, an increased interarm systolic blood pressure difference is associated with an increased risk for incident cardiovascular events, independent of traditional cardiovascular risk factors."

Researchers also found that participants with elevated interarm blood pressure difference were older, had a greater prevalence of diabetes mellitus, higher systolic blood pressure and a higher total cholesterol level.

According to these findings, investigators suggest practitioners should consider including blood-pressure readings in both arms in order to get the most accurate readings possible and detect any differences in interarm blood pressure. "Even modest differences in clinically measured systolic blood pressures in the upper extremities reflect an increase in cardiovascular risk," Weinberg said. "This study supports the potential value of identifying the interarm systolic blood pressure difference as a simple clinical indicator of increased cardiovascular risk."

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Researchers explore viability of self-administered flu vaccine patch

BY Michael Johnsen

ATLANTA — The annual ritual of visiting a doctor’s office or health clinic to receive a flu shot may soon be outdated, thanks to the findings of a new study published in the journal Vaccine.

The research, which involved nearly 100 people recruited in the metropolitan Atlanta area, found that test subjects could successfully apply a prototype vaccine patch to themselves. That suggests the self-administration of vaccines with microneedle patches may one day be feasible, potentially reducing administration costs and relieving an annual burden on healthcare professionals.

The study also suggested that the use of vaccine patches might increase the rate at which the population is vaccinated against influenza. After comparing simulated vaccine administration using a patch and by conventional injection, the percentage of test subjects who said they’d be vaccinated grew from 46% to 65%.

"Our dream is that each year there would be flu vaccine patches available in stores or sent by mail for people to self-administer," stated Mark Prausnitz, a Regent’s professor in the School of Chemical and Biomolecular Engineering at the Georgia Institute of Technology. "People could take them home and apply them to the whole family. We want to get more people vaccinated, and we want to relieve healthcare professionals from the burden of giving these millions of vaccinations."

In addition to Georgia Tech researchers, the project also included scientists from Emory University and the Centers for Disease Control and Prevention. Research into the use of microneedle patches for influenza vaccination has been supported by the National Institutes of Health.

The study is believed to be the first published report of a head-to-head comparison between microneedle patches and traditional intramuscular injection for the administration of vaccines in human subjects. The patches consisted of arrays of 50 microscopic needles about as tall as the thickness of a few hairs. When used for vaccination, the patches would be pressed painlessly onto a person’s forearm to carry vaccine into the outer layers of skin, where they would prompt an immune reaction from the body.

The 91 study subjects, who had no previous experience with microneedle patches, were given brief instructions on applying the patches to themselves. Each volunteer applied three patches, had a fourth patch applied by a member of the research team, and received an injection of saline with a conventional hypodermic needle. Neither the patches nor the hypodermic needle actually carried a vaccine, and the study did not assess the efficacy of using microneedle patches for vaccinations in humans.

The researchers evaluated how well the volunteers were able to self-administer the microneedle patches. After the subjects pressed the patches into their skin, the researchers applied a dye to highlight the tiny holes made by the microneedles. By photographing the administration sites and counting the number of holes, they were able to assess the accuracy of the application.

"We found that everyone was capable of administering a microneedle patch appropriately, though not everyone did on the first try," Prausnitz said.

Some of the subjects used an applicator that made a clicking sound when sufficient force was applied to the patch. Use of that feedback device improved the ability of subjects to correctly apply patches and virtually eliminated administration mistakes.

During the study, the volunteers were asked if they planned to receive a flu vaccination in the next year and if their intent to be vaccinated would change if it could be done with the patch. The percentage saying they’d be vaccinated jumped from 46% to 65% when the patch was an option.

"If this holds for the population as a whole, that would have a tremendous impact on preventing disease and the cost associated with both influenza and the vaccination process," stated Paula Frew, an assistant professor in the Emory University School of Medicine and a co-author of the study.

"In addition to the preference for the vaccine patch, we found that a large majority of the people willing to be vaccinated would choose to self-administer the vaccine," said James Norman, the study’s first author, who was a Georgia Tech graduate student when the research was conducted.

Study participants were asked to assess the pain associated with administering the patch and receiving the intramuscular injection. On a scale of 1 to 100, they rated the patches 1.5 on average, while the injection was rated 15.

If all goes well, the vaccine patch could be available within five years. Prausnitz expects it to be administered first by healthcare professionals before being made available for self-administration.

 

 

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