J&J, GSK start phase-3 trial program for rheumatoid arthritis drug
SPRING HOUSE, Pa. — A division of Johnson & Johnson has started a late-stage clinical trial program for a drug for rheumatoid arthritis under a partnership with British drug maker GlaxoSmithKline.
Janssen Biologics, based in Ireland, said it and GSK had started phase-3 studies of CNTO 136 (sirukumab), which the companies are investigating as a treatment for adults with moderately to severely active RA. The program includes two trials, SIRROUND-T and SIRROUND-D, which will assess how well CNTO 136 reduces signs and symptoms of the disease in patients who are allergic to certain drugs used to treat the disease.
"We are focused on advancing treatment options for chronic, debilitating autoimmune diseases such as rheumatoid arthritis," Janssen Research & Development VP and head of immunology development Jerome Boscia said. "We are pleased to be collaborating with GlaxoSmithKline on the clinical development of sirukumab, a protein therapeutic that we believe may represent an important treatment option for immunological diseases in the future."
New Rembrandt Gentle White toothpaste aims to gently whiten, reduce risk of irritation
NEW YORK — Oral care brand Rembrandt is expanding its product portfolio with its new Gentle White toothpaste, which is geared toward people prone to canker sores.
It is positioned as the category’s first whitening product focused on whitening without SLS, known to cause irritation, and helps strengthen tooth enamel to prevent daily acid wear, stated Johnson & Johnson Healthcare Products Division of McNEIL-PPC.
When one’s mouth is prone to irritations like canker sores, the ingredient SLS, found in some whitening toothpastes, can trigger those irritations. Citing data from National Institute of Dental and Craniofacial Research, the manufacturer stated that 19% of adults suffer from canker sores.
The new Rembrandt Gentle White is slated to hit shelves in September.
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Disney/Pixar brings ‘Brave’ home
Disney/Pixar is bringing its latest animated adventure to various Blu-ray combo packs and DVD this November.
Set in the ancient Highlands of Scotland, “Brave” follows young, rebellious Merida as she defies age-old traditions and begins a journey to discover the true meaning of bravery.
The Blu-ray release of “Brave” includes hours of new bonus material, behind-the-scenes features, extended and deleted scenes, the new short film “The Legend of Mor’du" and more.
The 5-Disc Ultimate Collector’s Edition, which includes one Blu-Ray 3-D disc, two Blu-Ray discs, one DVD and one digital copy, will debut Nov. 13 for a suggested retail price of $49.99. In addition, a 3-Disc Blu-ray Combo Pack will be available for a suggested retail price of $39.99. The 1-Disc DVD has a suggested retail price of $29.99.
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