IMS Health: Adherence, persistence issues keep diabetes costs high
PARSIPPANY, N.J. — The IMS Institute for Healthcare Informatics on Tuesday released a series of reports on type 2 diabetes and the effects of low persistence and adherence on health system. “Improving Type 2 Diabetes Therapy Adherence and Persistence” looked at five health systems, including the United States, Mexico, the United Kingdom, Germany, Brazil and Saudi Arabia.
In the U.S., the report noted that type 2 diabetes cost the healthcare system about $176 billion, with 61% of the cost coming from diabetes-related complications. Of those patients with type 2 diabetes, about 59% are older than 65 years of age, with a majority of them enrolled in Medicare. Among Medicare patients with diabetes, about 46% of them were sub-otpimally adherent, based on an analysis of 2014 patient records. Given these numbers, the IMS Institute estimates that complications from type 2 diabetes will cost about $100 billion annually in the United States, and $4 billion annually will attributable to the medicare population with diabetes.
“The rising prevalence of Type 2 Diabetes and its associated complications is the root of considerable strain on society and an economic burden on healthcare systems,” Murray Aitken, IMS Health SVP and executive director of the IMS Institute for Healthcare Informatics, said.
The IMS Institute notes that one of the biggest challenges is activating patients — helping them understand their role in the care process and getting them to take a more active stance when it comes to managing their disease. Activation can improve adherence and reduce healthcare costs as a result of increased adherence. But patient activation requires collaboration and solutions that can get patients activated and adherent.
“Simple, customized interventions that put patients on the path to optimal adherence and persistence can yield tangible results, but require alignment between healthcare and government leaders, as well as the active involvement of voluntary associations and the private sector,” Aitken said.
Among the recommendations the report makes for the U.S. are using predictive analytics to identify patients who might be sub-optimally adherent, offering educational content aimed at activating patients, incorporating healthcare plan counseling as part of medical appointments and using technology and digital offerings to maintain activation.
“The economic and societal burden of low [type 2 diabetes] therapy adherence and persistence to the U.S. Medicare system is high and rising,” the report says. “With nearly 12 million Medicare [persons with diabetes] in the U.S. today, estimated to grow to 17.2 million by 2025, it is imperative that structured action is taken to improve [type 2 diabetes] therapy adherence and persistence on a war footing.”
Nichi-Iko to acquire Sagent Pharmaceuticals
TOKYO AND SCHAUMBURG, Ill. — Japanese generic drug giant Nichi-Iko will be acquiring Sagent Pharmaceuticals, the two companies announced Tuesday. The $736 million all-cash transaction will see Nichi-Iko paying about a 40% premium on the closing price of the company’s shares at closing on July 8.
The move is aimed at Nichi-Iko becoming one of the top 10 global generics leaders, and the companies said acquiring Sagent will boost Nichi-Iko’s ability to commercialize its biosimilar pipeline and increase its presence in injectables. Sagent will gain access to Nicki-Iko’s manufacturing infrastructure and quality control systems. The companies said they don’t anticipate any changes to Sagent’s current operations.
“The U.S. market is a top priority for Nichi-Iko and we believe Sagent is an ideal partner to accelerate our international growth strategy,” Nichi-Iko president and CEO Yuichi Tamura said. “The company has a highly robust sales network, significant global relationships through its unique partner network, and an attractive portfolio of 55 products primarily in oncology, anti-infective, and critical care, of which 30% have a No. 1 or No. 2 market share. The combination will give us the opportunity to strengthen our international competitiveness, leverage our production capacity over a wider range of products, and accelerate development of our biosimilars business.”
The companies expect the deal to be complete in the second quarter of Nichi-Iko’s fiscal year, which ends in March 2017.
FDA makes big progress on GDUFA backlog
SILVER SPRING, Md. — The Food and Drug Administration’s Center for Drug Evaluation and Research has achieved its goal of clearing some of the backlog under the Generic Drug User Fee Agreement, according to an email sent by CDER director Janet Woodcock.
The agency has acted on more than 90% of backlogged applications for generics and prior approval supplements that were pewith FDA or industry as of Oct. 1, 2012. This puts the agency more than a year ahead of schedule, under the five-year funding period authorized by GDUFA, the FDA is required to clear the backlog by Sept. 30, 2017.
“Most applications from the backlog will need to come back to FDA for additional review before approval is possible, so we still have a lot of work ahead of us,” Woodcock’s email said. “But this is a significant milestone. We are exceeding our negotiated GDUFA commitments.”
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