PHARMACY

Cephalon ends Provigil agreement with Takeda

BY Alaric DeArment

NEW YORK Cephalon plans to end its agreement with Takeda Pharmaceutical to jointly promote the sleep-disorder drug Provigil in North America.

The agreement, made in 2006, allows either company to remove itself if sales fall below $850 million, which they did this year, though they had increased to almost $235 million in the second quarter of this year. Cephalon’s decision to pull out will take effect Nov. 1.

Provigil is known generically as modafinil.

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Teva’s Azilect slows Parkinson’s disease in trials

BY Alaric DeArment

WASHINGTON Results from a Phase III clinical trial have shown that Teva Pharmaceutical’s Azilect 1-mg tablets can slow the progression of the disease, the drug maker announced.

Researchers gave 1,176 Parkinson’s disease patients daily 1- to 2-mg doses of Azilect for 18 months or a placebo for the first nine months and the drug for the second nine months.

Patients who took the 1-mg dose of Azilect showed significant improvement compared with patients in the placebo group.

The Food and Drug Administration approved Azilect in May 2006 as a monotherapy for early-stage ParkinsonOs disease and as an adjunct therapy to levodopa in moderate-to-advanced stages of the disease.

The drug, known generically as rasagiline mesylate, is available in 30 countries. Danish drug maker Lundbeck markets it in Europe, and both companies plan to co-promote it in the United Kingdom, Germany and France.

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Taro to ask for extension on Sun Pharmaceuticals’ offer

BY Alaric DeArment

TEL AVIV,, Israel Taro Pharmaceutical Industries has said it will appeal to Israel’s Supreme Court to contest a ruling in the Tel Aviv District Court regarding India-based Sun Pharmaceuticals’ offer to acquire the Israeli generic drug maker.

The District Court judge had called Taro’s demand for a tender offer from Sun disingenuous, considering Taro’s acceptance of the offer a year ago.

Taro plans to ask the Supreme Court to extend the deadline for Sun’s offer, which was Tuesday at 5 p.m.

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